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Accueil > Interactions > Interdisciplinaires > Health Care and Biology : Modeling and simulation of blood flows in cerebral vascular network

Health Care and Biology : Modeling and simulation of blood flows in cerebral vascular network    fr

The team "Partial Differential Equations and Control Theory" has developed collaborations in these three areas:
- the simulation of blood flows in the human vascular system,
- the numerical rheology of the blood and
- the mass transfer from the vascular system (through the blood) to the surrounding tissues.

These different collaborations share many similarities and common toolchains and software are being setup.

Blood flows in cerebral vascular network

- Research team : Partial differential equations and control theory
- Contact : Marcela Szopos

Simulation d'écoulement dans le réseau cérébral Blood circulation is indeed a very complex multi-physics / multi-scale phenomenon. On the one hand, blood flow interacts both mechanically and chemically with vessel walls, giving rise to complex fluid-structure interactions. On the other hand, to account for the effect of the global circulatory system when focusing on specific regions, we need to integrate a hierarchy of models operating at different space and/or time scales. Consequently, complex mathematical and numerical models, together with high performance computer simulations need to be proposed in order to provide a valuable complement to experiments. Nowadays, developments of models, algorithms and computational environment make possible to use medical images (CT scan, MRI) as initial data in numerical computations. The huge amount of possibly noisy data and the complexity of geometrical structures require new mathematical and computer science developments. Moreover models and inputs are often poorly known. That is why we need to use and develop new uncertainty propagation and quantification methods for our problems.

A project concerning the development of virtual angiographic techniques is currently in progress as an interdisciplinary collaboration between members of the EDPTC team and the LSIIT department. The aim of the project is to construct a complete protocol allowing the generation of virtual angiographic images meant to visualise blood flow in a cerebral vascular network. The interest of virtual angiographies is that they may serve for validating image-based CFD models against routinely available clinical data. They can also provide a mean of visualising complex, three-dimensional blood flow dynamics in a clinically relevant manner. This project is currently supported by the French National Center for Scientific Research (CNRS) as a "Projet Exploratoire Pluridisciplinaire (PEPS)".

Dernière mise à jour le 14-12-2011